Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2006-2007
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2007
Report Date:
2007

Materials and methods

Principles of method if other than guideline:
Determination of solubility in octanol and calculation of log Pow with water solubility reported in section 4.8
Type of method:
other: calculation
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Study design

Analytical method:
photometric method

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
0.3
Temp.:
23
pH:
ca. 7
Type:
log Pow
Partition coefficient:
-0.52
Temp.:
23
pH:
ca. 7
Details on results:
Pow and log Pow were calculated from solubilities in octanol (see below) and in water (see section 4.8)

Any other information on results incl. tables

The solubility in octanol was determined to be 4.4 µg/L at ambient temperature (23-24°C). This figure represents the mean of 3 determinations (range: 2.3 -7.1 µg/L, sigma = 2.5). The solubility in water was determined to be 14.5 µg/L (section 4.8)

These solubilities are used to calculate Pow with the following equation:

Pow = solubility in octanol / solublity in water

Pow = 4.4 µg/L / 14.5 µg/L

Pow = 0.30

log Pow = -0.52

Applicant's summary and conclusion

Conclusions:
The test item has a log Pow of -0.52.

Executive summary:

The log Pow of the test substance was calculated from the solubilities in water and in octanol. The log Pow at 23 -24 °C was -0.52.