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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
other: literature search
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
other: secondary literature
Title:
Toxicology profile 2-octanol
Author:
anomnymous
Year:
1995
Bibliographic source:
BIBRA Toxicology advice & consulting

Materials and methods

Principles of method if other than guideline:
Single and repeated inhalation exposures (2-hour duration)/ no information on the method.

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC0
Effect level:
3.4 mg/L air
Mortality:
no mortality

Any other information on results incl. tables

The saturated vapour (unspecified concentration) had a slight toxic effect in mice when inhaled 2h (Zaeva & Fedorova, 1963b).

In an 18-week rat study, 2 hr daily exposures to atmospheres containing 180-350 mg/m3 produced slight decreases in the levels of heamoglobin (red blood cell pigment) and red blood cells, reduced neuromuscular, and caused tissue changes in the lungs heart liver kidneys, spleen, stomach and brain (Zaeva & Fedorova, 1963b).

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
slighlty harmful by inhalation.
Executive summary:

Secondary literature indicate that Octan-2-ol is slightly harmful by inhalation.