Registration Dossier
Registration Dossier
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EC number: 201-807-2 | CAS number: 88-18-6
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Japan MOE (1999) provided a 21 day NOEC of 0.32 mg/L o-sec-butylphenol, the structural analogue of o-tert-butylphenol.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.32 mg/L
Additional information
There are no reliable (Klimisch 1 or 2) long-term toxicity studies with invertebrates available with o-tert-butylphenol. However, a reliable long-term study with invertebrates is available for the structural analogue o-sec-butylphenol and is documented in this dossier.
Japan MOE (1999) conducted a reliable (Klimisch 1) GLP compliant long-term toxicity test following OECD 211 methods. Daphnia magna were exposed to measured concentrations of 0.0032, 0.01, 0.032, 0.1, 0.32, 1.0, and 3.2 mg/L of o-sec-butylphenol. The 21-day NOEC based on reproduction was 0.32 mg/L. Consequently this value will be taken as the long-term toxicity in aquatic invertebrates endpoint for o-tert-butylphenol.
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