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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Analogue approach: The target substance Camphene and the source substance 5-ethylidenebicyclo[2.2.1]hept-2-ene share the same organic functional group (cycloalkene).

Data source

Reference
Reference Type:
other: read-across
Title:
Unnamed
Year:
2010

Materials and methods

Principles of method if other than guideline:
The reporting form for analogue approach is attached.
GLP compliance:
not specified
Test type:
other: no data

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): 5-ethylidenebicyclo[2.2.1]hept-2-ene
- Molecular formula (if other than submission substance): C9H12
- Molecular weight (if other than submission substance): 120.19
- Smiles notation (if other than submission substance): C1(\[C@@H]2C[C@@H](C1)C=C2)=C\C
- InChl (if other than submission substance): InChI=1/C9H12/c1-2-8-5-7-3-4-9(8)6-7/h2-4,7,9H,5-6H2,1H3/b8-2+
- Structural formula attached as image file (if other than submission substance): see attached illustration.

Test animals

Species:
rabbit

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw

Any other information on results incl. tables

The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:

- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,

- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and

- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.

The reporting form for analogue approach is attached.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the dermal LD50 for the substance Camphene is also greater than 2000 mg/kg bw.
Executive summary:

The analogue 5-ethylidenebicyclo[2.2.1]hept-2-ene which shares the same functional group with Camphene, also has comparable values for the relevant molecular properties. These properties are:

- log Pow value which is 3.67 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.22 for Camphene,

- water solubility which is 15.91 mg/l at 25 ºC for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 4.2 mg/l for Camphene at 20 º C and

- similar molecular weights which are 120.19 for 5-ethylidenebicyclo[2.2.1]hept-2-ene and 136.23 for Camphene.

The dermal LD50 for the substance 5-ethylidenebicyclo[2.2.1]hept-2-ene is greater than 2000 mg/kg bw. Based on the read-across approach, the dermal LD50 for the substance Camphene is also greater than 2000 mg/kg bw.