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EC number: 618-561-0
CAS number: 9046-10-0
Skin irritation: Skin irritation studies of sufficient quality and
conducted in a method comparable to OECD guideline 404 showed that the
test substance was corrosive to rabbit skin.
Eye irritation: An eye irritation study of sufficient quality and
conducted in methods comparable to OECD guideline 405 showed that the
test substance was corrosive to rabbit eyes. pH value of 11.7 indicated
that the test substance was corrosive.
Erythema & Eschar
Sum of mean scores
Primary Dermal Index
Maximum Possible Score
Based on the results, the test substance was classified as a Group 3
substance (producing minor danger).
Cornea (max 80)
Iris (max 10)
Conjunctivae (max 20)
In one skin irritation study of sufficient quality and tested with
methods similar to OECD guideline 404, 0.5 mL test substance was applied
to the intact skin of rabbits (Pharmakon research International Inc,
1982; Klimisch 2). Animals were observed at 4 and 44 hours after
treatment. Signs of necrosis were visible in two of six rabbits at the 4
hour reading and in five of six rabbits at the 44 hour observation
In another skin irritation study tested with methods similar to OECD
guideline 404 (MB Research Laboratories Inc, 1979; Klimisch 2). 0.5 mL
test substance was applied to non-abraded and abraded skin of rabbits.
Animals were observed at 24 and 72 hours after treatment. The primary
dermal index was determined to be 6.54 indicating corrosivity.
In a skin irritation study conducted in methods comparable to OECD
guideline 404, 0.5 ml test substance was applied directly on the intact
skin sites (Pharmakon Research International Inc, 1984; Klimisch 2).
Animals were observed at 3 and 60 minutes and 4 hours after treatment.
No signs were observed at the 1-3 minute observation period. Slight to
moderate erythema was observed at the 60 minute and 4 hour observation
periods. Signs of necrosis were visible in one animal at the 4 hour
In a similar study, 0.5 mL test substance was applied to non-abraded and
abraded skin of rabbits for 1 hour (American Cyanamid company, 1968;
Klimisch 4). Animals were observed 72 hours after treatment. The primary
dermal index was determined to be 6.4. The degree of second degree
chemical burn was moderate and diffuse.
An in vitro skin irritation study does not need to be conducted because
adequate data from an in vivo skin irritation study are available.
In one eye irritation study of sufficient quality and tested with
methods similar to OECD guideline 405, 0.1 ml of the test substance was
instilled into one eye of each rabbit (MB Research Laboratories Inc,
1979; Klimisch 2). The ocular reactions were graded at 1, 24, 48 and 72
hours and again at 7 days. If any corneal score was present on day 7,
the eyes were scored again at 14 days. The maximum mean total scores
(MMTs) were 41.3, 55.7, 66.6, 61.4, 57.3, and 72 at 1h, 24h, 48h, 72h, 7
day, and 14 day, respectively. Cornea and conjunctivae effects were not
reversible within 14 days. The test substance was corrosive to rabbit
An in vitro eye irritation study does not need to be conducted because
adequate data from an in vivo eye irritation study are available.
Based on the available data, a classification category 1C is warranted
for skin irritation/corrosion.
Based on the available data, a classification category 1 (serious eye
damage) is warranted for eye irritation.
No study is available on respiratory irritation. Data for classification
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