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Melting point / freezing point

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melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09 November 2010 to 24 November 2010
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
This study was conducted in accordance with Method A1 "Melting/Freezing Temperature" of Commission Regulation (EC) No 440/2008 of 30 May 2008. This study was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994).

Data source

Reference Type:
study report

Materials and methods

Test guideline
according to guideline
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. QA statement)
Type of method:
other: BS4633

Test material

Constituent 1
Reference substance name:
Details on test material:
Identification: 3-trifluoromethylaniline
Description: Extremely pale yellow liquid
Purity: 99.66 %
Batch Number: 101009
Date Received: 25 October 2010
Storage Conditions: Room temperature in the dark

Results and discussion

Melting / freezing point
Melting / freezing pt.:
<= -4.5 °C

Any other information on results incl. tables

The results for the freezing temperature determinations indicated much super-cooling of the test item prior to solidifying. This effect was confirmed using differential scanning calorimetry (DSC), whereupon the test item did not freeze until the calorimeter had reached a temperature of -30 degrees celsius (243 kelvin), and then, upon warming, the test item melted at -13.4 degrees celsius (259.8 kelvin). The DSC thermogram is presented in the study report.

Due to the associated problems of super-cooling of the test item, a third freezing temperature determination was subsequently carried out, using crushed glass and a lower cooling rate in an attempt to aid the seeding process. However, the results again indicated much super-cooling of the test item, and a freezing temperature of -12 degrees celsius (261 kelvin).

Applicant's summary and conclusion

The freezing temperature has been determined to be less than or equal to 4.5 +/- 0.5 degrees celsius (278 +/- 0.5 kelvin). However, the results also indicated much super-cooling of the test item.

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