Registration Dossier
Registration Dossier
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EC number: 202-013-9 | CAS number: 90-72-2
Endpoint summary
Administrative data
Description of key information
Additional information
According to a Mackay Level I model calculation, the main target compartment for the substance will be the hydrosphere (99.996 %) followed by sediment and soil (0.002 % each).
The calculated Henry’s Law constant of 3.467E-7 Pa m³/mol at 20 °C indicates a very low volatility of the substance from surface waters. With a Koc of 20.98 l/kg, a low sorption potential of the substance to soil or sediment organic matter is expected (Blume scale).
The QSAR calculated rate constant for the OH sensitized photodegradation of the substance is approximately 252.38E-12 cm3/(molecule * s). At 500,000 OH radicals / cm3 (approximate 24-hour mean in central Europe), this corresponds to a half-life of 0.509 hours. Hydrolysis under environmental conditions is not to be expected.
No ready biodegradation could be expected.
2,4,6‐tris(dimethylaminomethyl) phenol attained 4 % degradation after 28 days in a Closed Bottle Test according to OECD 301D (Safepharm Laboratories, 1996). The partition coefficient 1-octanol/water of the test substance was determined as log Kow =-0.66 at 20 °C.
Without exception, all the 62 modelled degradation products of 2,4,6‐tris(dimethylaminomethyl) phenol were estimated to exhibit log Kow values of clearly ≤4.5 (see Table 1 of endpoint entry), thereby not fulfilling the screening criteria for bioaccumulation (B/vB) as laid down in Section 3.1 of REACH Annex XIII.
However, 12 predicted relevant metabolites present in concentration of ≥0.1% (~ equivalent to quantity setting in OASIS CATALOGIC: 0.001-2 [mol/mol parent]) should be considered as potentially P/vP from a precautionary point of view.
Thus, based on modeled data relevant degradation products present in concentration of ≥ 0.1% (~ equivalent to quantity setting in OASIS CATALOGIC: 0.001 -2 [mol/mol parent]) do neither fulfill the PBT criteria (not PBT) nor the vPvB criteria (not vPvB).
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