Registration Dossier
Registration Dossier
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EC number: 204-463-1 | CAS number: 121-30-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 121-30-2
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Ames mutagenicity. Multicase model A2H.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-amino-6-chlorobenzene-1,3-disulphonamide
- EC Number:
- 204-463-1
- EC Name:
- 4-amino-6-chlorobenzene-1,3-disulphonamide
- Cas Number:
- 121-30-2
- Molecular formula:
- C6H8ClN3O4S2
- IUPAC Name:
- 4-amino-6-chlorobenzene-1,3-disulfonamide
- Details on test material:
- - Name of test material: 4-amino-6-chlorobenzene-1,3-disulphonamide
- Molecular formula: C6H8ClN3O4S2
- Molecular weight: 285.73
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
Results and discussion
Test results
- Species / strain:
- bacteria, other: Salmonella typhimurium
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Ames test (Salmonella) for 4-amino-6-chlorobenzene-1,3-disulphonamide is estimated to be negative. - Executive summary:
Ames test (Salmonella) for 4-amino-6-chlorobenzene-1,3-disulphonamide is estimated to be negative.
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