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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 121-30-2
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-EPI Suite (DERMWIN) Various versions of EPI Suite dating back from 1990-2004.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
EPI Suite (DERMWIN)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
4-amino-6-chlorobenzene-1,3-disulphonamide
EC Number:
204-463-1
EC Name:
4-amino-6-chlorobenzene-1,3-disulphonamide
Cas Number:
121-30-2
Molecular formula:
C6H8ClN3O4S2
IUPAC Name:
4-amino-6-chlorobenzene-1,3-disulfonamide
Details on test material:
- Name of test material: 4-amino-6-chlorobenzene-1,3-disulphonamide
- Molecular formula: C6H8ClN3O4S2
- Molecular weight: 285.73
- Substance type: Organic
- Physical state: Solid
Radiolabelling:
not specified

Test animals

Species:
other: no data
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified

Results and discussion

Percutaneous absorption
Remarks on result:
other: Dermal absorption value: 0.00016 mg/cm2/event (VERY LOW)

Applicant's summary and conclusion

Conclusions:
Dermal absorption value of 4-amino-6-chlorobenzene-1,3-disulphonamide is estimated to be 0.00016 mg/cm2/event (VERY LOW).
Executive summary:

According to Danish QSAR database Dermal absorption value of 4-amino-6-chlorobenzene-1,3-disulphonamide is estimated to be 0.00016 mg/cm2/event (VERY LOW).