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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information from data bank, no study details were provided. It is not clear if the administered dose refers to the 10 % solution prepared or to BCEE. This causes uncertainty in the interpretation of the results

Data source

Reference
Reference Type:
other: internet data base
Title:
GESTIS Substance database
Author:
German Social Accident Insurance
Year:
2012
Bibliographic source:
http://www.dguv.de/ifa/en/gestis/stoffdb/index.jsp

Materials and methods

Principles of method if other than guideline:
no information provided
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-chloroethyl) ether
EC Number:
203-870-1
EC Name:
Bis(2-chloroethyl) ether
Cas Number:
111-44-4
Molecular formula:
C4H8Cl2O
IUPAC Name:
1-chloro-2-(2-chloroethoxy)ethane

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
propylene glycol
Remarks:
10% solution
Duration of exposure:
24 h.

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
90 mg/kg bw
Remarks on result:
other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the BCEE content.
Sex:
not specified
Dose descriptor:
LD50
Effect level:
9 mg/kg bw
Remarks on result:
other: It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the ai content. As worst case scenario, it is assumed that the LD50 is based on the total applied material. Hence, the LD50 based on ai is 10% of the applied amount

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category I
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

The data base contains following statement:

For rabbits, an LD50 value of 90 mg/kg bw resulted from skin contact with a 10 % BCEE solution in propylene glycol for 24 hours.

No further information was provided.

It is not stated if the reported LD50 of 90 mg/kg bw is based on the applied substance or the BCEE content. As worst case scenario, it is assuemed that the LD50 is based on the total applied material. Hence, the LD50 based on BCEE is 10% of the applied amount, i.e., 9 mg/kg bw.