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EC number: 203-149-1
CAS number: 103-83-3
RS-Freetext:Mortality:Dose: 445 890 1246 1780Deaths (%): 0 0 0 100 Time: - - - 1-2 d LD50: 1.66 ml/kg (1.35-2.04) = 1477 mg/kgSigns of toxicity:Tremors, immediate hyperactivity, vocalisation, weight loss, only in the highest dose group, death within 1-2 days.Edema and necrosis with formation of scabs at the site of application within the observation period of 14 d.Gross necropsy:Deaths: mottled appearance of liver and kidneysSurvivors: no abnormal findings
In an acute dermal toxicity study the undiluted test substance was
applied to the clipped dorsal skin of groups containing 4 male
rabbits/group at doses of 0.5, 1.0, 1.4, 2.0 ml/kg bw. The test material
was maintained in contact with the skin by a polythene sheet held in
place with an adhesive dressing. Animals were immobilized during a 24-hr
occlusion period. At the end of the contact period the polythene
sheeting was removed, the skin gently wiped clean, and the area
inspected for signs of local inflammation. Animals were observed daily
over a 14-day postapplication period for signs of toxicity. At the end
of this time the survivors were sacrificed and subjected to autopsy
examination. All animals died at the highest dose of 2.0 ml/kg bw, with
a latency of up to 2 days. Signs of toxicity included tremors and
hyperactivity. No signs of systmic toxicity were seen in animals
following the application of 1.4 ml/kg bw and lower. On removal of the
occlusive dressing, edema and necrosis were seen at the site of
application of undiluted test substance to skin. This progressed to scab
formation over the ensuing 14 days. Autopsy examination of the animals
that died revealed a red mottled appearance to the liver and kidneys,
but otherwise there were no abnormalities. The LD50 was determined to be
1.66 ml/kg bw (ca1477 mg/kg bw).
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