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EC number: 203-978-9
CAS number: 112-50-5
ORAL - RATS (mg/kg): 10600DERMAL LD50 (mg/kg)TEGME read across substance: Rabbit: 7.45mg/kgTEGBE read across substance: Rabbit: 3.45ml/kg
In an old but reliable acute oral toxicity study, male albino rats were
administered single doses of 2-(2-(2-ethoxyethoxy)ethoxy)ethanol by
gavage. The LD50 was calculated at 10.61g/kg. In a poisoning case, a
young child self administered a huge dose estimated in excess of 25g/kg
of a formulated brake fluid based on triethylene glycol ethers. Whilst
intensive medical support was briefly required, the patient made a full
There is however measured data for two substances either side of it in
the homologous series of these triethylene glycol ethers. A full and
detailed justification for a category approach for meeting the
individual data requirements for glycol ethers is included as an
attachment in chapter 13 to this dossier. For this specific end point,
Chapter 13 of the IUCLID dossier submitted by the lead registrant
contains a full and detailed justification for using a category approach
to fulfil the data requirements for glycol ethers and to specifically
justify the use of read across for certain end points, including this
one. The analysis included in this document shows
there is a clear trend towards reducing toxicity vertically down a
homologous series. Interpolation between the results of other glycol
ethers within the same homologous family of triethylene glycol ethers
can be considered a valid approach to meeting the data requirements of
this substance. Data for the two analogue substances
is shown below:
In an acute dermal toxicity study in rabbits under occluded conditions
with the substance 2 -(2 -(2 -methoxyethoxy)ethoxy)ethanol in which key
basic details were reported, an LD50 of 7100mg/kg was obtain. In an
acute dermal toxicity study under occluded conditions using the
substance 2 -(2 -(2 -butoxyethoxy)ethoxy)ethanol in rabbits, in which
only basic details were reported, an LD50 of 3540mg/kg was obtain. It is
reasonable to conclude that the acute LD50 by the dermal route for the
substance 2 -(2 -(2 -ethoxyethoxy)ethoxy)ethanol will fall somewhere
between these two values.
No acute toxicity data is available by the inhalation route but the
extremely low volatility of this substance and low acute toxicity by
other routes leads to the conclusion that such data is not required to
conclude that there is no acute toxicity hazard by the inhalation route.
The available data indicates that this substance is of very low acute
toxicity by all routes of exposure and classification is not warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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