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EC number: 204-596-5 | CAS number: 123-05-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Additional information
No data available.
Effects on developmental toxicity
Description of key information
NOAEL: developmental toxicity: 300.9 mg/kg bw/day
NOAEL: maternal toxicity: 300.9 mg/kg bw/day
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 300.9 mg/kg bw/day
Additional information
Developmental toxicity of 2-ethylhexanal was assessed according to OECD guideline 414 Huntingdon 1999; Val 1). 2-ethylhexanal was administered by daily oral gavage to rats from day 6 to 19 of their pregnancy, at dosages up to 797.6 mg/kg bw/day. There was no obvious adverse maternal toxicity at 100.0 or 300.9 mg/kg bw/ day. In contrast, at 797.6 mg/kg bw/day there was clear evidence of maternal toxicity (piloerection and underactivity, eyelids partly closed and hunched posture; low food consumption and reduction of overall absolute and adjusted bodyweight gain). Embryo-fetal survival was unaffected by treatment with 2-Ethylhexanal.
At 300.9 mg/kg bw/day, fetal weights were lower and there was delayed ossification. The relationship of these findings to treatment is uncertain. Beyond this, they are considered to be transient in nature, rather than representing permanent structural changes. Therefore the slight fluctuations in fetal weights and some ossification parameters are not considered to be of toxicological relevance during later development. According to the authors other effects observed at 300.9 mg/kg are either with in the range of the historical control (rudimentary/ absent renal papillae; dilated ureter) or marginal and not dose related (displaced testes) or only slightly increased but possible artefacts (haemorrhages of brain/spinal cord). Therefore these effects were considered not to be substance related and of no toxicological relevance.
At 797.6 mg/kg bw/day fetal and placental weights were reduced and placental abnormalities were observed in a few litters, e.g. pale placenta (3 litters; about 10% of the placenta overall). Fetal pathology revealed visceral and skeletal abnormalities at 797.6 mg/kg bw/day (visceral: dilated brain ventricles, absent/rudimentary thyroid gland, cardiovascular abnormalities and rudimentary/absent renal papillae; skeleton: reduction in ossification, rib and vertebral abnormalities and changes in configuration not related to fetal immaturity). Fetal immaturity was noted universally at 797.6 mg/kg bw/day and, to a lesser extent, at 300.9 mg/kg bw/day.
In conclusion, there was no evidence of adverse maternal or embryo-fetal toxicity at 100.0 mg/kg bw/day. Similarly, at 300.9 mg/kg bw/day no obvious adverse maternal toxicity was seen but there was some delayed ossification. Effect is considered to be transient in nature, rather than representing permanent structural changes and of no toxicological relevance during later development . At 797.6 mg/kg bw/day, maternal toxicity was clearly evident and 2 -ethylhexanal is toxic to the developing embryo and fetus. The NOAEL for both, maternal toxicity and developmental toxicity is considered to be 300.9 mg/kg bw/day.
Justification for classification or non-classification
Based on the available data and according to the criteria of EU Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, 2 -ethylhexanal is classified with R63 (possible risk of harm to the unborn child) and H361d (suspected of damaging the unborn child).
Additional information
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