Registration Dossier
Registration Dossier
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EC number: 205-572-7 | CAS number: 142-92-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
An Ames test performed with hexyl acetate in S. typhimurium TA98, TA100, TA102, TA1535 and TA1535 reports an inconsistentlty positive result in TA102 only, in the absence of metabolic activation. This result was not replicated in a follow-up study by the same authors performed in TA102 only. A negative result is reported in an Ames test performed using the read-across substance n-butyl acetate; a negative result is also reported in an assay of clastogenicity in CHL cells with n-butyl acetate.
Justification for selection of genetic toxicity endpoint
A weight of evidence approach is used for this endpoint.
Short description of key information:
Ames tests are available for hexyl acetate and the read-across substance n-butyl acetate; a clastogenicity study in vitro is available for n-butyl acetate.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Following a weight of evidence approach, the results of genotoxicity studies in vitro do not indicate that hexyl acetate is genotoxic. No classification is therefore required according to the CLP Regulation.
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