Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-957-4 | CAS number: 112-31-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
Although REACH does not specifically require generation of toxicokinetic information, it does require that all relevant available information is used to assess the toxicokinetic behaviour of a substance, and that human health hazard assessment considers the toxicokinetic profile of the substance.
Decanal is a small organic molecule and the physico-chemical properties suggest it is likely to be absorbed via dermal, inhalation and gastric routes following exposure.
Acute and subchronic toxicity data indicate that Decanal is absorbed following administration by gavage and metabolised by the liver. No specific studies on the absorption, distribution, metabolism and elimination (ADME) of are available. However the very low toxicity of Decanal suggests that it may be considered inappropriate at this time to conduct further animal work to support ADME.
Decanal: (Target)
Molecular weight: 156.27 Da
Water solubility: 29.4 mg/L in ultrapure water
Partition coefficient: log Kow = 3.8
The following remarks on the toxicokinetics of Decanal are based on the available.
Experimental toxicokinetic studies were not available.
No specific studies on the absorption, distribution, metabolism and elimination (ADME) of Decanal are available. However the very low toxicity of Decanal suggests that it may be considered inappropriate at this time to conduct further animal work to support ADME.
ABSORPTION
The physicochemical characteristics of Decanal (log Pow 3.8) and the molecular mass are in a range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion. This assumption of oral absorption is confirmed by the data from the subchronic oral toxicity.
N-octanol/water partition coefficient and molecular weight of Decanal are in ranges which favour dermal absorption.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. This assumption is confirmed by the changes shown in the repeated dose toxicity studies following oral application.
ELIMINATION
The n-Octanol/water partition coefficient (log Pow 3.8) is suggestive of accumulation of unchanged Decanal in fatty tissues subsequent to absorption from gastrointestinal tract or from lungs.
The following information is taken into account for any hazard / risk assessment:
Experimental toxicokinetic studies are not available. The log Pow 3.8) is suggestive of accumulation of unchanged Decanal in fatty tissues subsequent to absorption from gastro-intestinal tract or from lungs.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
