Registration Dossier
Registration Dossier
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EC number: 202-377-9 | CAS number: 94-96-2
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The substance shows substantial first-pass metabolism by the liver after oral exposure, and is rapidly eliminated from the blood, primarily in the urine, after intravenous dosing.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 20
- Absorption rate - dermal (%):
- 1
Additional information
The pharmacokinetics of 2-ethyl-1,3-hexanediol, administered intravenously, were examined in rats at high and low doses. Values for pharmacokinetic parameters were obtained which indicate metabolism by the liver (80%) and rapid elimination from the blood, primarily in the urine. Absorption through the skin of rats is slow. A comparative study between the absorptive parameters of human, rat and rabbit skin was undertaken in vitro with undiluted EHD and a 3% aqueous solution of EHD. Female rabbit skin absorbed undiluted EHD most effectively, followed by rat and lastly, human. Human skin absorbed less than 1% of the administered concentration of undiluted EHD. Absorption of undiluted EHD was approximately 3-fold higher in rats than in human skin. Absorption of dilute EHD (3% aqueous solution in water) was comparable between rat and human, but half the amount absorbed by rabbit skin.
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