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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
key study
Rationale for reliability incl. deficiencies:
other: Non-GLP, Non-guideline study. Available as a published report. Acceptable with restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975

Materials and methods

Principles of method if other than guideline:
Groups of 10 Male ICR mice were administered DIBP undiluted ip and observed 7 days for mortality. These were compared to a control who were administed with cornseed oil.
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Supplied by Eastman Chemicals, Kingsport, Tennessee.

Test animals

Species:
mouse
Strain:
ICR
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
unchanged (no vehicle)
Details on exposure:
7 days
No. of animals per sex per dose:
10 male mice per dose level
Control animals:
yes
Details on study design:
- Duration of observation period following administration: 7 days
Control animals aministed cottonseed oil only.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LC50
Effect level:
3.99 other: g/kg b.w.
Based on:
test mat.
95% CL:
3.91

Applicant's summary and conclusion

Conclusions:
The LD50 for DIBP was 3.99 g/kg. (95% Confidence Interval 3.91-4.08.)
Executive summary:

This study was conducted prior to the implementation of OECD guidelines and GLP, but followed methods of the time and contains sufficient detail for assessment. It is considered suitable for use as a key study for this endpoint.