Registration Dossier
Registration Dossier
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EC number: 201-553-2 | CAS number: 84-69-5
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study. Available as a published report. Limitations on reporting. Acceptable with restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Procedure as described in Wolfe et al. (1976) Agric. Food Chem., 24, 1041 and Wolfe et al (1977) Environ. Sci & Tech., 11, 88
Sodium hydroxide induced hydrolysis is monitored by GLC on samples. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Diisobutyl phthalate
- EC Number:
- 201-553-2
- EC Name:
- Diisobutyl phthalate
- Cas Number:
- 84-69-5
- Molecular formula:
- C16H22O4
- IUPAC Name:
- 1,2-bis(2-methylpropyl) benzene-1,2-dicarboxylate
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- LC- 0.3 M KH2PO4
- Details on test conditions:
- Tests were carried out at 30.00 +/- 0.05 ⁰C, never exceeding 10-5M and always below the water solubility of the ester.
Duration of test
- Temp.:
- 30
- Number of replicates:
- Not reported
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- None
Results and discussion
Dissipation DT50 of parent compound
- Temp.:
- 30 °C
- Hydrolysis rate constant:
- 0.001
- St. dev.:
- 0
- Type:
- second order
- Remarks on result:
- other: Units: M-1.s-1
- Details on results:
- Second order hydrolysis rate constant = (1.4 ± 0.2) * 10-3 M-1.s-1
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The second order hydrolysis rate constant of diisobutyl phthalte was found to be 0.0014 ± 0.0002 M-1.s-1
- Executive summary:
In a non-GLP, non-guideline study the second order hydrolysis rate constant of diisobutyl phthalte was found to be 0.0014 ± 0.0002 M-1.s-1
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