o-anisidine

Dermal absorption

Administrative data

Endpoint:

dermal absorption in vivo

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

year of publication: 2002

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only secondary source

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

review article or handbook

Title:

European Union Risk Assessment Report - o-Anisidin

Author:

European Chemicals Bureau

Year:

2002

Bibliographic source:

European Commission, Joint Research Center, EUR 19834 EN, 2nd Priority list, Volume 15

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

o-anisidine

EC Number:

201-963-1

EC Name:

o-anisidine

Cas Number:

90-04-0

Molecular formula:

C7H9NO

IUPAC Name:

2-methoxyaniline

Results and discussion

Signs and symptoms of toxicity:

yes

Remarks:

ataxia, lacrimation, eyelid constriction, ruffeled fur, at day 1 post application urine was orange

Dermal irritation:

yes

Remarks:

very slight to moderate irritative effects 30 min post application which were all reversible within 72 h

Any other information on results incl. tables

Dermal resorption can be assumed from other studies on toxicity of o-anisidine.

Applicant's summary and conclusion

Conclusions:

There were no in vivo studies specifically dealing with the metabolism of o-anisidine. However, from effects observed in toxicological studies it can be assumed that o-anisidine is resorbed after dermal application.