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EC number: 200-772-0
CAS number: 72-17-3
RS-Freetext:No significant gross observations, with the exception ofminimal skin irritation. Absolute brain weight andkidney-to-body weight ratios were increased for testanimals.No lesions were observed at necropsy or at microscopicexamination.
All animals survived to study termination. No significant gross
observations, with the exception of minimal skin irritation throughout
the study, could be attributed to dosing. During week 7, the blood urea
nitrogen value was significantly increased for test ammals as compared
to controls; no other hematological effects were seen, and urinary
parameters were normal. Absolute brain weight and kidney-to-body weight
ratios were statistically significantly increased for the test animals.
No lesions were observed at necropsy or at microscopic exammation. The
investigators concluded this formulation is "safe in terms of cumulative
toxicity" and that "based upon the exaggerated dose level used in this
study for skin care products, dermal application is not likely to
produce adverse effects under conditions of consumer use."
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