Registration Dossier
Registration Dossier
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EC number: 203-140-2 | CAS number: 103-74-2
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable calculation method
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: software application
- Title:
- US EPA . Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.10 . United States Environmental Protection Agency, Washington, DC, USA ; ECOSAR™ Version 1.11 [2012]
- Author:
- U.S. Environmental Protection Agency 1200 Pennsylvania Ave., N.W. (Mail Code 7406M) Washington, DC 20460
- Year:
- 2 013
- Bibliographic source:
- http://www.epa.gov/oppt/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs Chapter R.6 , May 2008
- Principles of method if other than guideline:
- The estimation for short-term toxicity to daphnia of the test material was performed with US-EPA software ECOSAR v1.11. ECOSAR is currently programmed to identify over 120 chemical classes. For those classes, there are a more than 600 QSARs based on publicly available experimental data and confidential studies collected under the EPA New Chemicals Program. For each class, a standard EPA New Chemicals Program aquatic toxicity profile will be created using available QSARs and/or alternate QSAR approaches and professional judgment.
- GLP compliance:
- no
- Remarks:
- (not applicable)
Test material
- Reference substance name:
- 2-(2-pyridyl)ethanol
- EC Number:
- 203-140-2
- EC Name:
- 2-(2-pyridyl)ethanol
- Cas Number:
- 103-74-2
- Molecular formula:
- C7H9NO
- IUPAC Name:
- 2-(pyridin-2-yl)ethan-1-ol
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report) : 2-Pyridineethanol
- SMILES : n(c(ccc1)CCO)c1
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable
Sampling and analysis
- Analytical monitoring:
- not required
- Details on sampling:
- Not applicable
Test solutions
- Details on test solutions:
- Not applicable
Test organisms
- Test organisms (species):
- other: daphnia , not further specified
- Details on test organisms:
- No details available
Study design
- Test type:
- other: QSAR estimation
- Water media type:
- not specified
- Total exposure duration:
- 48 h
- Post exposure observation period:
- Not applicable
Test conditions
- Hardness:
- No details available
- Test temperature:
- No details available
- pH:
- No details available
- Dissolved oxygen:
- No details available
- Salinity:
- No details available
- Nominal and measured concentrations:
- No details available
- Details on test conditions:
- No details available
- Reference substance (positive control):
- not required
- Remarks:
- (not applicable)
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1 415.289 mg/L
- Remarks on result:
- other: calculated value ECOSAR CLass : Neutral Organics
- Details on results:
- No details available
- Results with reference substance (positive control):
- Not applicable
- Reported statistics and error estimates:
- Not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Remarks:
- (Scientifically accepted calculation method.)
- Conclusions:
- The study report describes a scientifically accepted calculation method for the prediction of short-term toxicity to daphnia using the US-EPA software ECOSAR v1.11.No GLP criteria are applicable for the usage of this tool and the QSAR estimation is easily repeatable.
- Executive summary:
The prediction for short-term toxicity to daphnia of the test substance was determined by the computer program ECOSAR v1.11 by US-EPA .ECOSAR is currently programmed to identify over 120 chemical classes. For those classes, there are a more than 600 QSARs based on publicly available experimental data and confidential studies collected under the EPA New Chemicals Program. For each class, a standard EPA New Chemicals Program aquatic toxicity profile will be created using available QSARs and/or alternate QSAR approaches and professional judgment.
The Prediction for ECOSAR Class Neutral Organics resulting in a value for daphnia LC50(48h) of 1415.289 mg/L .
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