3-chloro-p-toluidine

Guidance on Safe Use

First-aid measures

General advice: Move out of dangerous area. Consult a physician. Show this safety data sheet to the doctor in attendance. Symptoms of poisoning may appear several hours later. Do not leave the victim unattended.

If inhaled: If unconscious, place in recovery position and seek medical advice.

In case of skin contact: Wash the skin immediately with plenty of soap and water; cleaning immediately with polyethylene glycol 400 and washing subsequently with plenty of soap and water would be more effective.

Carefully clean hair, under the nails, and other hidden areas. In case of blueness of lips, skin or nails (cyanosis) let the per-son breathe oxygen. No physical exertion. No consumption of alcohol after product contact.

In case of eye contact: Immediately flush eye(s) with plenty of water. Remove contact lenses. Protect unharmed eye. Keep eye wide open while rinsing.

If eye irritation persists, consult a specialist.

If swallowed: Call a physician immediately. DO NOT induce vomiting unless directed to do so by a physi-cian or poison control center. Keep respiratory tract clear. Do not give milk or alcoholic beverages. Never give anything by mouth to an unconscious person. If symptoms persist, call a physician.

Most important symptoms and effects, both acute and delayed: Toxic if swallowed. Fatal in contact with skin. Causes mild skin irritation. May cause an allergic skin reaction. Causes eye irritation. Harmful if inhaled.

Notes to physician: Elementary aid, decontamination, symptomatic treatment and depending on the formation of methaemoglobin: intravenous administration of toluidine blue or other redox dyes according to dosage specifications plus ascorbic acid.

Fire-fighting measures

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Hazardous combustion products: Carbon dioxide (CO2), Carbon monoxide, Nitrogen oxides (NOx), Halogenated compounds,

Specific extinguishing methods: Collect contaminated fire extinguishing water separately. This must not be discharged into drains. Fire residues and contaminated fire extinguishing water must be disposed of in accordance with local regulations. Cool closed containers exposed to fire with water.

Special protective equipment for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.

Accidental release measures

Personal precautions, protec-tive equipment and emergency procedures: Use personal protective equipment. Do not breathe vapours/dust.

Environmental precautions: Prevent product from entering drains. Prevent further leakage or spillage if safe to do so. If the product contaminates rivers and lakes or drains inform respective authorities.

Methods and materials for containment and cleaning up: Vacuum or sweep up material and place in a designated, labelled waste container. Dispose of wastes in an approved waste disposal facility.

Reference to other sections: See Section First-aid measures, see Section Exposure controls / personal protection, see section Disposal considerations.

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been  received  from affected  Distributor and  Downstream Manufacturer/User of the Registrant´s intermediate.

Advice on safe handling: Persons susceptible to skin sensitisation problems or asthma, allergies, chronic or recurrent respiratory disease should not be employed in any process in which this mixture is being used. Avoid inhalation of vapour or mist. Avoid contact with skin and eyes.

For personal protection see section Exposure controls / personal protection.

Dispose of rinse water in accordance with local and national regulations.

Conditions for safe storage: Take action to prevent static discharges. Prevent unauthorized access. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Observe label precautions. Electrical installations / working materials must comply with the technological safety standards.

Further information on storage stability: No decomposition if stored and applied as directed

Recommended packing materials: Use original container.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN2239

Shipping information

Proper shipping name and description:

Chlorotoluidines, solid

Chemical name:

3-chloro-p-toluidine

Language:

English

Labels:

Slightly toxic; Environmetally hazardous substance; Irritating to skin and eyes; Keep separated from foodstuffs.

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN2239

Shipping information

Proper shipping name and description:

Chlorotoluidines, solid

Chemical name:

3-chloro-p-toluidine

Language:

English

Labels:

Slightly toxic; Environmetally hazardous substance; Irritating to skin and eyes; Keep separated from foodstuffs.

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN2239

Shipping information

Proper shipping name and description:

Chlorotoluidines, solid

Chemical name:

3-chloro-p-toluidine

Labels:

Slightly toxic; Environmetally hazardous substance; Irritating to skin and eyes; Keep separated from foodstuffs.

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN2239

Shipping information

Proper shipping name and description:

Chlorotoluidines, solid

Chemical name:

3-chloro-p-toluidine

Labels:

Slightly toxic; Environmetally hazardous substance; Irritating to skin and eyes; Keep separated from foodstuffs.

Remarks

Additional transport information

Additional information

Special provisions / remarks / other:

Slightly toxic; Environmetally hazardous substance; Irritating to skin and eyes; Keep separated from foodstuffs.

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been  received  from affected  Distributor and  Downstream Manufacturer/User of the Registrant´s intermediate.

Exposure limit values: Not available.

Recommended monitoring procedures: If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to monitoring standards, such as the following: European Standard EN 689 (Workplace atmospheres - Guidance for the assessment of exposure by inhalation to chemical agents for comparison with limit values and measurement strategy) European Standard EN 14042 (Workplace atmospheres - Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents) European Standard EN 482 (Workplace atmospheres - General requirements for the performance of procedures for the measurement of chemical agents) Reference to national guidance documents for methods for the determination of hazardous substances will also be required.

Risk management measures

Occupational exposure controls

Technical measures: Use only with adequate ventilation. The substance shall be rigorously contained by technical means during its whole lifecycle

including manufacture, purification, cleaning and maintenance of equipment, sampling, analysis, loading and unloading of equipment or vessels, waste disposal or purification and storage. Procedural and control technologies shall be used that minimise emission and any resulting exposure. In cases of accident and where waste is generated, procedural and/or control technologies shall be used to minimise emissions and the resulting exposure.

during purification or cleaning and maintenance procedures.

Organisational measures:  Only properly trained and authorised personnel shall handle the substance. In the case of cleaning and maintenance works, special procedures such as purging and washing shall be applied before the system is opened and entered.

Engineering measures: Handle only in a place equipped with local exhaust (or other appropriate exhaust).

Personal protective equipment

Respiratory protection: In the case of vapour formation use a respirator with an approved filter.

Filter type: Combined inorganic and acidic gas/vapour, ammonia/amines and organic vapour type

Hand protection Material: Butyl rubber - IIR, Wearing time: < 60 min

Material: Polyvinyl chloride - PVC, Wearing time: < 60 min

Material: Fluorinated rubber - FKM, Wearing time: < 60 min

Material: Polychloroprene - CR, Wearing time: < 60 min

Remarks: The suitability for a specific workplace should be discussed with the producers of the protective gloves. After contamina-tion with product change the gloves immediately and dispose of them according to relevant national and local regulations

Eye protection: Tightly fitting safety goggles

Skin and body protection: Impervious clothing. Choose body protection according to the amount and concen-tration of the dangerous substance at the work place.

Hygiene measures: Avoid contact with skin, eyes and clothing. When using do not eat or drink. When using do not smoke. Wash hands before breaks and immediately after handling the product.

Environmental exposure controls

Technical measures: Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Stability and reactivity

Reactivity: No specific test data related to reactivity available for this product or its ingredients.

Chemical stability: Stable under normal conditions.

Possibility of hazardous reactions: Under normal conditions of storage and use, hazardous reac-tions will not occur.

Conditions to avoid: No hazardous reactions when used as directed.

Incompatible materials: No specific data.

Hazardous decomposition products: No hazardous decomposition products are known.

Disposal considerations

Disposal methods

Waste from residues: The product should not be allowed to enter drains, water courses or the soil. Do not contaminate ponds, waterways or ditches with chemi-cal or used container. Send to a licensed waste management company.

Contaminated packaging: Empty remaining contents. Dispose of as unused product. Do not re-use empty containers.