Registration Dossier
Registration Dossier
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EC number: 202-446-3 | CAS number: 95-74-9
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Title:
- No information
- Author:
- National Cancer Institute: Bioassay of 3-chloro-p-tolu-|idine for possible carcinogenicity. NCI Carcinogenesis|Technical Report Series No. 145 (1978)
- Reference Type:
- publication
- Title:
- 3-Chloro-p-Toluidine
- Author:
- Bureau of National Affairs
- Year:
- 1 995
- Bibliographic source:
- Bureau of National Affairs, INC, Washington, D.C. 20037
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 002
- Details on test material:
- IUCLID4 Test substance: other TS: 3-chloro-p-toluidine; high purity (no further data)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 78 w
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
see remarks
Basis:
- Control animals:
- yes
- Details on study design:
- Post-exposure period: 25 w (24 w only for the males and at the higher concentration)
Results and discussion
Any other information on results incl. tables
Although a dosage-dependent increased incidence of endometrial stromal polyps was observed in the female rats,
it was found to be statistically insignificant (incidences:
0 % (control), 8 % (low dose), 18 % (high dose)); the authors contend that this lesion is common in aged female
Fischer 344 rats, and the variation in its incidence among
the control and dosed rats is attributed to the low number of control females; an incidence of 28/284 (10 %) was
noted for the historical control; under the test conditions,
the study did not provide any convincing indications of
carcinogenicity of 3-chloro-p-toluidine in Fischer 344 rats.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
