Registration Dossier
Registration Dossier
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EC number: 202-446-3 | CAS number: 95-74-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable and sufficinet documented
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Principles of method if other than guideline:
- Undiluted 3-chloro-p-toluidine was applied on the shaved belly skin of rats for 4 hours in doses of 100 to 1000 µl/kg (117 to 1170 mg/kg). After 4 hours the substance was removed with water and soap. The animals were observed for 7 days.
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- 95-75-9
- IUPAC Name:
- 95-75-9
- Reference substance name:
- 3-chloro-p-toluidine
- EC Number:
- 202-446-3
- EC Name:
- 3-chloro-p-toluidine
- Cas Number:
- 95-74-9
- Molecular formula:
- C7H8ClN
- IUPAC Name:
- 3-chloro-4-methylaniline
- Test material form:
- other: liquid
- Details on test material:
- technically pure, undiluted 3-chloro-p-toluidine
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 4 hours
- Doses:
- 100 µl (= 117 mg)/kg bw, 250 µl (= 292.5 mg/kg bw), 500 µl (= 585 mg/kg bw), 600 µl (= 702 mg/kg bw), 800 µl (= 936 mg/kg bw), 1000 µl (= 1170 mg/kg bw).
- No. of animals per sex per dose:
- 5 rats (100 µl), 5 rats (250 µl), 10 rats (500 µl), 10 rats (600 µl), 10 rats (800 µl), 5 rats (1000 µl).
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 765 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
From 2 to 6 hours after application of the test substance,typical signs of intoxication (cyanosis, laboured breathing, sedation) were observed. The highest dose without findings was 100 µl (117 mg/kg bw) and the lowest lethal dose was 600 µl (702 mg/kg bw).
Applicant's summary and conclusion
- Executive summary:
Undiluted 3-chloro-p-toluidine was applied on the shaved belly skin of rats for 4 hours in doses of 100 to 1000 µl/kg (117 to 1170 mg/kg bw). After 4 hours the substance was removed with water and soap. The animals were observed for 7 days.
LD50 (4 hours exposure) = 650 µl 3-chloro-p-toluidine/kg bw (= ca. 765 mg/kg bw).
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