1,3-propanesultone

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

other: Exposure related observations in humans

Adequacy of study:

key study

Reliability:

4 (not assignable)

Data source

Reference

Reference Type:

review article or handbook

Title:

1,3-Propane sultone, an extremely potent experimental carcinogen: what should be expected in humans?

Author:

Bolt, M. H. and Golka, K.

Year:

2004

Bibliographic source:

Toxicology Letters 151, 251–254

Materials and methods

Type of study / information:

Case studies and related malignancies observed in persons exposed to 1,3-propane sultone are described.

Endpoint addressed:

carcinogenicity

Test material

Test material information

Constituent 1

Reference substance name:

1,3-propanesultone

EC Number:

214-317-9

EC Name:

1,3-propanesultone

Cas Number:

1120-71-4

Molecular formula:

C3H6O3S

IUPAC Name:

1,2λ⁶-oxathiolane-2,2-dione

Results and discussion

Any other information on results incl. tables

During manufacturing mainly in the 1950s and 1960s exposure of a limited amount of workers could have occurred and the medical history of some cases could be traced. As cerebral gliomas are the main systemic tumours induced by 1,3-propanesultone experimentally, the occurrence of a glioblastoma among previously exposed persons appears conspicuous. Three intestinal malignancies were recorded among the cases observed. Also noteworthy is one case of a duodenal carcinoma, normally a rare human malignancy. Two haematopoietic/lymphatic malignancies of different nature have been observed, and there was one case of a renal cell carcinoma. These observations within a group of persons exposed to 1,3-propanesultone appear consistent with the expectations from the available animal studies.