Oxydipropyl dibenzoate

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5 June 1997 - 21 August 1997

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes

Type of method:

flask method

Water solubility:

ca. 8.69 mg/L

Temp.:

20 °C

pH:

7

Details on results:

It was evident from the chromatography data that the monobenzoate impurity DPGMB is significantly more soluble relative to DPGDB. Note that soluble impurities may influence water solubility measurement.

The mean recovery of DPGDB from water was determined to be 91.6%. Such recoveries imply that the extraction procedure employed was quantitative, and so no corrections for spike recovery were performed.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The solubility of DPGDB was determined as 8.69 mg/L at 20ºC and pH 7.
The low solubility may mean that the endpoints of some studies may reach the limit of solubility before a result is obtained.

Executive summary:

A package of testing including a determination of water solubility was conducted to determine the physico-chemical properties of the test material DPGDB. The determination of water solubility was performed according to OECD and EC test guidelines, and in compliance with GLP. The test used the shake flask method and analysis by gas chromatography.

The solubility of DPGDB was found to be 8.69 mg/L at 20 ºC and pH7.

Reference 2

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

18 May 1998 - 28 May 1998

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

Use of natural and non-buffered water

GLP compliance:

yes

Water solubility:

8.43 mg/L

Temp.:

25 °C

Remarks on result:

other: Pure water, reference standard

Water solubility:

7.97 mg/L

Temp.:

25 °C

Remarks on result:

other: Pure water, technical

Water solubility:

8.2 mg/L

Temp.:

25 °C

Remarks on result:

other: Softened dechlorinated water, reference standard

Water solubility:

6.92 mg/L

Remarks on result:

other: Softened dechlorinated water, technical

Water solubility:

8.3 mg/L

Remarks on result:

other: Dechlorinated water, reference standard

Water solubility:

7.71 mg/L

Remarks on result:

other: Dechlorinated water, technical

Water solubility:

8.45 mg/L

Remarks on result:

other: River water, reference standard

Water solubility:

7.71 mg/L

Remarks on result:

other: River water, technical

Details on results:

Recovery experiments were performed for river water. At the lowest concentration of 0.05 mg/L accurate quantitation was not possible. Recoveries were close to nominal levels at both 1 and 7.5 mg/L (nominal) in unfiltered samples but reduced to approximately 60 - 75% in filtered samples.
These results support the view that the DPGDB may not be in true solution in unfiltered samples.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The aqueous solubility of dipropylene glycol dibenzoate both for the reference standard and technical material, was between 6.92 - 8.45 mg/L (mean values) in pure, soft and hard dechlorinated and river water

Executive summary:

A study was performed to determination of water solubility of the test material DPGDB, both in the form of a reference standard and technical material, in pure, soft and hard dechlorinated and river water . The determination of water solubility was performed according to OECD 105 test guideline, and in compliance with GLP.

Samples of DPGDB were shaken with water for 24 hours at 25ºC. Samples were analysed by HPLC.

The solubility of DPGDB was found to be between 6.92 - 8.45 mg/L and comparable in the different types of water an grade of test material.

Reference 3

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

6 August 1999 - 14 August 1999

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted before GLP in force

Qualifier:

no guideline followed

Principles of method if other than guideline:

Investigation into possible losses of dipropylene glycol dibenzoate from dechlorinated water before and after filtration and/or centrifugation

GLP compliance:

yes

Remarks on result:

not determinable

Details on results:

Losses from the samples are detailed below
Concentration: 0.02 mg/L
No treatment: No loss
Filtration: 45%
Centrifugation: 8.3%
Filtration and centrifugation: 53.6%

Concentration: 0.2 mg/L
No treatment: No loss
Filtration: 61.1%
Centrifugation: 15.4%
Filtration and centrifugation: 66.0%

Concentration: 2.0 mg/L
No treatment: No loss
Filtration: 55.3%
Centrifugation: 8.0%
Filtration and centrifugation: 57.6%

It is concluded that losses due to filtration are primarily due to extraction from the aqueous phase into the filter.
The reason for the losses due to centrifugation are not known.

Conclusions:

Samples of dechlorinated water fortified with DPGDB in the concentration range 0 02 to 2 0 mg/L show losses of compound when filtered and/or centrifuged.
It is unlikely that these losses are due to the physical removal of undissolved DPGDB by either technique. The losses due to filtration are probably primarily due to extraction from the aqueous phase into the filter. The losses resulting from centrifugation are much smaller and the reason for them is uncertain.
Overall these results were compatible with DPGDB having a water solubility greater than 2 mg/L.

Executive summary:

A study was performed to determine whether DPGDB would be lost from aqueous solution as a result of sample pre-treatment.

Significant losses were were associated with filtration, with smaller losses associated with centrifugation.

Overall the results were compatible with DPGDB having a water solubility greater than 2 mg/L.

Description of key information

The solubility of DPGDB was found to be 8.69 mg/L at 20ºC and pH7 (HLS 1999, VCL249/972399).

Key value for chemical safety assessment

Water solubility:

8.69 mg/L

at the temperature of:

20 °C