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EC number: 203-815-1
CAS number: 110-91-8
dermal toxicity and skin absorption of Morpholine was assessed in one
investigation using rabbits. Unneutralized, diluted Morpholine (1 part
Morpholine, 2 parts water) was applied at a daily dose of 900 mg/kg bw
to the clipped skin of the midsection of a group of 7 rabbits. All
rabbits died before the eleventh dose. Necrosis of the treated skin, and
inflammation and congestion of the underlying organs were evident upon
gross examination. Microscopic lesions of the liver included pale
nuclei, necrosis, cell breakdown, congestion, cloudy swelling, and areas
of fibrosis and fatty change. The kidneys had an "abnormal amount of
secretion" in the tubules, and the spleen was congested with a perfusion
of erythrocytes. The lung and stomach were normal under nontreated
sites; however, these organs were "friable" when under the area of
direct Morpholine application. The skin was necrotic and congested after
the ninth and tenth application. The heart appeared normal upon
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