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EC number: 203-815-1 | CAS number: 110-91-8
In this toxicokinetic study provided by Tanaka et al. (1977), elimination, distribution and metabolism of Morpholine salts in rats were investigated by means of chemical analysis and/or radioassay. Gas-liquid chromatography was used for chemical analysis of Morpholine in the rat urine and faeces. The distribution of 14C-labeled Morpholine via oral administration (200 mg/kg bw) or i.v. injection (150 mg/kg bw) to 3 male animals per group was investigated. The analytical results of the excreta accorded with those made by the tracer technique. When rats were given Morpholine-HCl or -palmitate, about 90% of the dose was excreted in the urine over a period of 3 days and the remaining in the faeces (0.08 to 0.14 %). Morpholine was largely excreted unchanged in the urine: Ninety percent of the original dose was found in the urine after 3 days. The lowest affinity was found for adipose regardless of routes of administration. The elimination of Morpholine from organs, tissues and blood was generally rapid and specific organ-affinity was not observed in other organs except the intestine. The highest level was found in the muscle and intestine.
This toxicokinetic study in the rat is as classified acceptable.
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