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EC number: 203-815-1
CAS number: 110-91-8
Based on the GHS, no chronic toxicity is anticipated at an NOEC or EC10 > 1 mg/L.
The long-term toxicity to aquatic
invertebrates was assessed in an OECD 211 study using Daphnia magna as
test organism (NITE, 1997). Based on the reproduction the following
effect values were determined: 21-d NOEC = 5 mg/L; 21-d EC50 = 12 mg/L
(based nominal concentrations, verified by analytical measurement). The
originally reported data were re-evaluated with ToxRat Professional
v3.2.1 (BASF SE, 2017) resulting in a 21-d EC10 of 8.134 mg/L
(21-d EC50 = 12.191 mg/L).
Remark on assessment:
The assessment of the long-term
toxicity to aquatic invertebrates is based on the 21-d EC10 of 8.134
mg/L (recalculated with ToxRat v3.2.1) and not on the 21-d NOEC of 5.0
mg/L originally reported in the study. According to the Guidance on
information requirements and chemical safety assessment Chapter R.10:
Characterisation of dose [concentration]-response for environment ", an
EC10 for a long-term test which is obtained using an appropriate
statistical method (usually regression analysis) will be used
preferentially. [...] There has been a recommendation within OECD in
1996 to phase out the use of the NOEC, in particular as it can
correspond to large and potentially biologically important magnitudes of
effect. The advantage of regression method for the estimation of ECx is
that information from the whole concentration-effect relationship is
taken into account and that confidence intervals can be calculated.
These methods result in an ECx, where x is a low effect percentile (e.g.
5-20%). It makes results from different experiments more comparable than
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