Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Short-term toxicity to fish:

With high probability not harmful to fish.

LC50 (96 h): > 100 mg/L (Oryzias latipes, semi-static conditions, analytically verified concentrations)


Long-term toxicity to fish:

No experimental data available.

NOEC (ACR method): > 1 mg/L


Short-term toxicity to aquatic invertebrates:

Morpholine is acutely harmful to aquatic invertebrates.

EC50 (48 h): 45 mg/L (Daphnia magna, OECD 202, static)


Long-term toxicity to aquatic invertebrates:

EC10 (21 d): 8.134 mg/L (Daphnia magna, OECD 211, semi-static)


Growth inihibition to aquatic algae:

Morpholine is acutely toxic to aquatic algae.

ErC50 (72 h): 65 mg/L (Pseudokirchneriella subcapitata, OECD 201, static, analytically verified concentrations)

ErC10 (72 h): 31 mg/L (Pseudokirchneriella subcapitata, OECD 201, static, analytically verified concentrations)


Toxicity to microorganisms:

The inhibition of the degradation activity of activated sludge is not anticipated when introduced to biological treatment plants in appropriate low concentrations.

EC20 (30 min): > 1000 mg/L (OECD 209; one test with domestic activated sludge and two tests with industrial activated sludge)

EC3 (16 h): 310 mg/L (Pseudomonas putida, growth inhibition test)

Additional information