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EC number: 266-582-5
CAS number: 67124-09-8
per Minute, Disintegrations per Minute/Node and Stimulation
Concentration (% w/w) in
Acetone/olive oil 4:1
disintegrations per minutes
Stimulation Index of 3.0 or greater indicates a positive result
N/A = Not
clinical Observations and Mortality Data
redness on the ears was noted in animals treated with the undiluted test
item. There were no deaths. No
signs of systemic toxicity were noted in the test or control
during the test.
Bodyweights and Bodyweight Changes
weight changes of the test animals between Day 1 and Day 6 were
comparable to those
observed in the corresponding control group animals over the same period.
results of the statistical
analysis of the data indicated there was no significant difference
between the vehicle control group and the test item groups. The concentration of test item expected to cause a 3 fold increase in 3HTdR
was calculated to be14%.
study was performed to assess the skin sensitization potential of the
test material in the CBA/Ca strain mouse following topical application
to the dorsal surface of the ear. The method was designed to meet the
requirements OECD 429 and Method B42.
a preliminary screening test in which no clinical signs of toxicity were
noted at a concentration of 50% w/w, this concentration was selected as
the highest dose investigated in the main test of the Local Lymph Node
1: three groups, each of five animals, were treated with 50 μl (25 μl
per ear) of the test material undiluted or as a solution in
acetone/olive oil 4:1 at concentrations of 50% or 25% or 10% w/w;A
further group of five animals was treated with acetone/olive oil 4:1
alone. The pool
method was used;
2: three groups, each of five animals, were treated with the test item
at concentrations of
25%, 10% and 2.5% v/v in acetone/olive oil 4:1. An additional group of five animals was treated with
4:1 alone. A concurrent positive control test, using a
five animals, was
also performed with
the known sensitiser, a-Hexylcinnamaldehyde
tech., 85%, at a concentration of
25% v/v in acetone/olive oil 4:1.
Stimulation Index expressed as the mean radioactive incorporation for
each treatment group divided by the mean radioactive incorporation of
the vehicle control group are as follows:
per Minute, Disintegrations per Minute/Node and Stimulation Index
to the calculation the concentration of test material expected to cause
a 3 fold increase in 3HTdR incorporation (EC3 value) was found to be 14%.
test material was considered to be a sensitiser under the conditions of
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