Registration Dossier
Registration Dossier
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EC number: 201-956-3 | CAS number: 89-98-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1979
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Insufficiently documented data from literature
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of toxic doses of o-chlorobenzylidene malonitrile (CS) in the rabbits
- Author:
- Paradowski M
- Year:
- 1 979
- Bibliographic source:
- Pol. J. Pharmacol. Pharm. 31, 563-572
Materials and methods
- Principles of method if other than guideline:
- acute intravenious toxicity
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2-chlorobenzaldehyde
- EC Number:
- 201-956-3
- EC Name:
- 2-chlorobenzaldehyde
- Cas Number:
- 89-98-5
- Molecular formula:
- C7H5ClO
- IUPAC Name:
- 2-chlorobenzaldehyde
- Details on test material:
- - Name of test material (as cited in study report): o-chlorobenzaldehyde
- Analytical purity: min. 98%, distilled freshly prior to use
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intravenous
- Vehicle:
- DMSO
- Doses:
- 4 dose levels (not further specified)
- No. of animals per sex per dose:
- 4 animals in each group (no information on sex of the animals)
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 8.5 other: mg/kg
- 95% CL:
- 6.5 - 11.2
Applicant's summary and conclusion
- Executive summary:
The LD50 value of 2-chlorobenzaldehyde in rabbits after intravenious administration and 24 hrs observation period was 8.5 mg/kg bw.
The study has been judged not to be reliable (RL3) due to insufficient documentation.
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