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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1977
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Non-guideline study, insufficient documentation, only report of results without documentation of details
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1977

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-chlorobenzaldehyde
EC Number:
201-956-3
EC Name:
2-chlorobenzaldehyde
Cas Number:
89-98-5
Molecular formula:
C7H5ClO
IUPAC Name:
2-chlorobenzaldehyde
Details on test material:
- Name of test material (as cited in study report): o-chlorobenzaldehyde (E-757)

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
other: impervious cuff
Vehicle:
not specified
Duration of exposure:
no data
Doses:
5.0 to 20.0 g/kg
No. of animals per sex per dose:
3 animals at all

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
approximate LD50
Effect level:
20 000 mg/kg bw

Applicant's summary and conclusion

Executive summary:

In a study with guinea pigs which were dermally exposed to 5.0 to 20.0 g 2-chlorobenzaldehyde/kg bw no deaths were recorded.

Due to insufficient reporting the study was judged not to be reliable (RL3).