Tosyl chloride

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1976

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Indirect reference: Report of study to EPA as referenced in OECD SIDS dossier on 4-methylbenzenesulfonyl chloride; very limited reporting; no guideline study applying only one animal at three dose levels each.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

2003

Materials and methods

Test type:

other: No data

Test material

Test material information

Constituent 1

Reference substance name:

Tosyl chloride

EC Number:

202-684-8

EC Name:

Tosyl chloride

Cas Number:

98-59-9

Molecular formula:

C7H7ClO2S

IUPAC Name:

4-methylbenzenesulfonyl chloride

Details on test material:

4-Methylbenzenesulfonyl chloride, Lot No. – QH-5095,
no further data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Vehicle:

corn oil

Details on dermal exposure:

no data

Duration of exposure:

24 hours

Doses:

3,160, 5,010 and 7,940 mg/kg

No. of animals per sex per dose:

1

Control animals:

no

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 010 mg/kg bw

Based on:

test mat.

Mortality:

The animals dosed at 3160 mg/kg (1 male) and 5010 mg/kg (1 female) both survived.
One male animal that was dosed at 7940 mg/kg, died within 9 days.

Clinical signs:

Sign of intoxication: reduced appetite and activity (2 - 3 days in survivors). Increased weakness, collapse, death

Gross pathology:

Necropsy: lung hyperomia, liver & kidney discolouration, enlarged gall bladder, gastrointestinal inflammation

Any other information on results incl. tables

Mortality:

Animal No.	Dose	Weight (Ave)		Mortality			Time of mortality
		M	F	M	F	Combined
1	3,160	220	-	0/1	-	0/1	9 days
2	5,010	-	180	-	0/1	0/1
3	7,940	210	-	1/1	-	1/1

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

LD50 > 5010 mg/kg.

Executive summary:

Tosyl chloride was applied as a 40% solution-suspension in corn oil on the skin of New Zealand Albino Rabbits for 24 hours. The levels were 3160, 5010 and 7940 mg/kg bw , that were applied to respectively one male, one female and one male animal.

There were some signs of intoxication, consisting of reduced appetite and activity for 2 - 3 days in two survivors that were treated with 3160 and 5010 mg/kg bw. The animal treated with 7940 mg/kg bw showed increased weakness, collapse, and death after 9 days. At necropsy, lung hyperaemia, liver & kidney discolouration, enlarged gall bladder, and gastrointestinal inflammation were observed. The LD50 was concluded to be greater than 5,010 mg/kg.