Registration Dossier
Registration Dossier
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EC number: 212-472-7 | CAS number: 821-06-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short description
Data source
Reference
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- Shell Chemical Company. Unpublished report. 2401 Cro Canyon Rd., San Romon, CA 94583
- Year:
- 1 961
- Bibliographic source:
- cited in RTECS, EM4725000, 2006
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
Test material
- Reference substance name:
- (E)-1,4-dibromobut-2-ene
- EC Number:
- 212-472-7
- EC Name:
- (E)-1,4-dibromobut-2-ene
- Cas Number:
- 821-06-7
- Molecular formula:
- C4 H6 Br2
- IUPAC Name:
- 1,4-dibromobut-2-ene
- Details on test material:
- No data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- 500 mg
- Duration of treatment / exposure:
- No data
- Observation period:
- No data
- Number of animals:
- No data
- Details on study design:
- No data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: irritation
- Basis:
- other: no data
- Time point:
- other: no data
- Score:
- > 2
- Reversibility:
- not reversible
- Remarks on result:
- other: The data indicate that the test substance is corrosive (causes severe damage) to the skin although no scores are available.
- Irritant / corrosive response data:
- severe skin damage
- Other effects:
- No data
Any other information on results incl. tables
Results for the study are only available in descriptive form.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
