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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Referred in a recognized source of peer reviewed scientific data on chemicals

Data source

Reference
Reference Type:
review article or handbook
Title:
Experimental acute toxicity of vinyl Chloride (monochloroethene).
Author:
Prodan L, Suciu I, Pîslaru V, Ilea E, & Pascu L
Year:
1975
Bibliographic source:
Ann NY Acad Sci, 246: 154–158.

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Chloroethylene
EC Number:
200-831-0
EC Name:
Chloroethylene
Cas Number:
75-01-4
Molecular formula:
C2H3Cl
IUPAC Name:
chloroethene

Test animals

Species:
other: rodents

Administration / exposure

Route of administration:
inhalation: gas
Type of inhalation exposure:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
390 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: rats
Sex:
not specified
Dose descriptor:
LC50
Effect level:
293 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: mice
Sex:
not specified
Dose descriptor:
LC50
Effect level:
595 mg/m³ air
Exp. duration:
2 h
Remarks on result:
other: Guinea-pigs
Sex:
not specified
Dose descriptor:
LC50
Effect level:
295 mg/m³ air
Remarks on result:
other: rabbits

Any other information on results incl. tables

Overview of experimental studies on acute toxicity of chloroethylene after inhalation

Method

 

Results

Remarks

Reference

Rodents, inhalation

Guideline: not known

LC50 (2-h, rats)=390 000 mg/m3;

LC50 (2-h, mice)=293 000 mg/m3

LC50 (2-h, Guinea-pigs)=595 000 mg/m3

LC50 (2-h, rabbits)=295 000 mg/m3

 

 

Peer-reviewed data summarised in the World Health Organization (WHO) review report of vinyl chloride

 

Prodan L, Suciu I, Pîslaru V, Ilea E, & Pascu L (1975) Experimental acute toxicity of vinyl

Chloride (monochloroethene). Ann NY Acad Sci, 246: 154–158.

Applicant's summary and conclusion

Conclusions:
The cut-off value for classification of substances for acute inhalation toxicity for gases is LC50= 20 000 ppm (v/v). All published data for chloroethylene report LC50 values higher than 20 000 ppm.
It is, therefore, considered that chloroethylene is of low acute toxicity in experimental animals by inhalation.