Registration Dossier
Registration Dossier
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EC number: 201-928-0 | CAS number: 89-65-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate,Erythorbic Acid, and sodium Erythorbate
- Author:
- F. Alan Andersen
- Year:
- 1 999
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Litton Bionetics, Inc performed activation and non-activation suspernsion tests using homogenates of liver, lungs, and testes and suspensions from adult male ICR mice, Sprague-Dawley rats, and Macca mulatta primates. The indicator organisms were S. typhimurium strains TA-1535, TA-1537, and TA-1538, and Saccharomyces cerevisiae strain D4.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- EC Number:
- 201-928-0
- EC Name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- Cas Number:
- 89-65-6
- Molecular formula:
- C6H8O6
- IUPAC Name:
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Test results
- Species / strain:
- other: TA-1535,TA-1537,TA-1538 and Scccharomyces cerevisiae strain D4
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Remarks:
- Not mentioned in the review article
- Remarks on result:
- other: other: homogenates of liver, lungs, and testes and suspensions from adult ICR mice, Sprague Dawley rats and Macaca mulatta primates.
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
