Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only limited documentation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167.
Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in BUA (1995) Phenylhydrazine. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (Report No. 120; ISBN 3-7776-0691-X).
Reference Type:
secondary source
Title:
Concise International Assessment Document 19: Phenylhydrazine
Author:
WHO
Year:
2000
Bibliographic source:
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
Reference Type:
secondary source
Title:
Unnamed
Year:
1994

Materials and methods

Principles of method if other than guideline:
50 % solution of phenylhydrazine is applicated to the eyes of rabbits.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL
- Concentration (if solution): 50 %
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Irritation parameter:
other: Irritation
Basis:
other: no data
Time point:
other: no data
Score:
> 0
Reversibility:
not specified
Remarks on result:
other: The available data clearly indicates that the test substance is irritating to the eye although no scores have been provided.
Irritant / corrosive response data:
see remarks on results
Other effects:
no data

Any other information on results incl. tables

Results are only available in descriptive form. The application of a 50 % solution of phenylhydrazine to the eyes of rabbits caused severe suppurative conjunctivitis.

Applicant's summary and conclusion

Interpretation of results:
Category 2A (irritating to eyes) based on GHS criteria
Remarks:
Migrated information