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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Limited documentation

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in BUA (1995) Phenylhydrazine. Stuttgart, S. Hirzel, Wissenschaftliche Verlagsgesellschaft (Report No. 120; ISBN 3-7776-0691-X).
Reference Type:
publication
Title:
Toxicity of phenylhydrazine in inhalatory exposure
Author:
Pham KC
Year:
1979
Bibliographic source:
Gigiena Truda i Professional'nye Zabolevaniya, 3:45-47; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167.
Reference Type:
secondary source
Title:
Concise International Assessment Document 19: Phenylhydrazine
Author:
WHO
Year:
2000
Bibliographic source:
Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
Reference Type:
secondary source
Title:
Unnamed
Year:
1994

Materials and methods

Principles of method if other than guideline:
Determination of LC50 values for an unstated exposure period.
GLP compliance:
no
Test type:
other: Inhalation procedure with whole body exposure

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
no data

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
other: no data
Details on inhalation exposure:
no data
Analytical verification of test atmosphere concentrations:
not specified
Remarks on duration:
no data
Concentrations:
No data about the tested concentrations. According to the original publication LC50 was 2.61 +/- 0.37 mg/L.
Cited in WHO 2000, LC50 was determined as 2745 mg/m³ (610 ppm).
Cited in UBA 1994, LC50 was identical to the original publication (2.61 +/- 0.37 mg/L).
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
no data
Statistics:
No statistics was performed.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
2.61 mg/L air
Remarks on result:
other: no data about exposure duration
Mortality:
no details
Clinical signs:
respiratory disorder such as other methemoglobin formers
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Applicant's summary and conclusion