Undec-10-enal

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

accepted calculation method

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.

The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain.

GLP compliance:

no

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Reference substance (positive control):

not specified

Key result

Duration:

48 h

Dose descriptor:

LC50

Effect conc.:

1.197 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

not specified

Remarks on result:

other: Neutral Organics SAR

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of EPI suite, ECOSAR, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 1.197 mg/l for test chemical in 48 hrs.
Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

Executive summary:

Based on the prediction done by EPI suite, ECOSAR, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted.

On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 1.197 mg/l for test chemical in 48 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

Description of key information

Based on the prediction done by EPI suite, ECOSAR, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 1.197 mg/l for test chemical in 48 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.197 mg/L

Additional information

Summarized result for the toxicity of test chemical and structurally and functionally similar read across chemicals were reviewed and mention as below:

Based on the prediction done by EPI suite, ECOSAR, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted. On the basis of this program, the LC 50 value for short term toxicity to aquatic invertebrates was predicted to be 1.197 mg/l for test chemical in 48 hrs. Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can be classified in aquatic chronic 2 category as per the criteria mentioned in CLP regulation.

 

Above result was supported by the second data from authoritative database. Objective of this study was to evaluate the range of toxicity of test chemical on the mobility of daphnia magna. Test conducted in accordance with OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) for 48 hrs under the static system. Based on the immobility of daphnia magna after the exposure period of 48 hrs, EC50 was determine to be 1.3 mg/l. Thus based on the EC50 value, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.

 

Similar short term toxicity study for aquatic invertebrate Daphnia magna was performed for the test chemical according to OECD Guideline 202. The test concentration were0.13, 0.25, 0.50, 1.0, 2.0, 4.0 mg/l. Dimethyl formamide) was used as a solvent control. No immobilization occurred in the control or in the solvent control group. No immobilization was noted after 48 hours up to the treatment level of 0.25 mg/L. After 48 hours immobilization in the treatment groups of 0.50, 1.0, 2.0 and 4.0 mg/L was 15 %, 30 %, 30 % and 75 % respectively. The effect concentration for 50% immobilization of Daphnia magna after 48 h short term toxicity test was observed to be 2.3 mg/l. Based on the EC50 value, chemical consider to be toxic and classified in aquatic chronic 2 as per the CLP classification criteria.

 

Similar short term toxicity of test material was evaluated for 48 h according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test).HCO-40 was used in this test to prepare the test solution due to low water solubility and the limit test at 5.00 mg/L was performed. The EC50 after 48 h was evalauted to be >5.00 mg/l. EC50 (48h) was greater than the concentration used in the limit test because there was only 10 % immobility during the exposure. No effects were observed till the last limit of solubility.

 

Thus based on the overall studies and effects, chemical consider to be toxic and classified as aquatic chronic 2 as per the CLP classification criteria.