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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
in vivo mammalian somatic cell study: cytogenicity / bone marrow chromosome aberration
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Study period:
August, 2019
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model, but not (completely) falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
See attached QPRF

Data source

Reference
Title:
Unnamed
Year:
2019

Materials and methods

Test guideline
Guideline:
other: QSAR

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): OS#16980AH
- Physical state: dark amber colored liquid
- Storage condition of test material: room temperature in the dark
- Other:

Results and discussion

Test results
Genotoxicity:
negative

Applicant's summary and conclusion

Executive summary:

 A prediction of the dialkyl dithiophosphate ester (dissociated from Zn) was conducted using OASIS TIMES in vivo micronucleus v.11.11. The prediction was negative for the parent and metabolites. The prediction was within the parametric domain and 70.97% in the structural fragment domain.