Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

The dermal sensitisation potential of TAEE was assessed in a GLP-compliant murine local lymph node assay (Method B.42 of Commission Directive 2004/73/EEC). In this study, TAEE gave Stimulation Indices less than 3 when tested at concentrations of 100%, 50% or 25% v/v in acetone/olive oil (4:1). Alpha-hexylcinnamaldehyde (positive control substance) gave a Stimulation Index of greater than 3 when tested at 15% v/v in acetone/olive oil (4:1) (Harlan Laboratories Ltd, 2009e).

The results of this study demonstrate that TAEE is not a skin sensitiser.


Migrated from Short description of key information:
TAEE is not a skin sensitiser.

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:
Migrated from Short description of key information:
Respiratory tract sensitisation is not expected as the substance contains no structural alerts and since no positive human data are available.

Justification for classification or non-classification

Based on the available data, TAEE is considered to be not sensitising. In accordance with Directive 67/548/EEC and EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008, classification is not necessary for sensitisation.