Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline not specified, GLP status unknown, article available in Japanese (abstract English), acceptable with restrictions. No analytical purity of the tested MTBE sample was reported.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1984

Materials and methods

Principles of method if other than guideline:
Not specified (see below)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
No details given
Specific details on test material used for the study:
Details on properties of test surrogate or analogue material (migrated information):
No data
Radiolabelling:
no

Sampling and analysis

Details on sampling:
No data

Test solutions

Vehicle:
not specified
Details on preparation of test solutions, spiked fish food or sediment:
No data

Test organisms

Test organisms (species):
Cyprinus carpio
Details on test organisms:
No data

Study design

Route of exposure:
aqueous
Test type:
flow-through
Water / sediment media type:
not specified
Total exposure / uptake duration:
28 d
Total depuration duration:
14 d

Test conditions

Hardness:
No data
Test temperature:
25 °C
pH:
No data
Dissolved oxygen:
No data
TOC:
No data
Salinity:
No data
Details on test conditions:
No data
Nominal and measured concentrations:
Measured concentrations: 9.7 (wk 1) - 9.8 (wk 2) - 9.6 (wk 3) - 10.2 (wk 4) ppm
Reference substance (positive control):
not specified
Details on estimation of bioconcentration:
No data

Results and discussion

Bioaccumulation factor
Type:
BCF
Value:
1.5 L/kg
Basis:
whole body w.w.
Remarks on result:
other: Conc.in environment / dose:10.2 mg/l
Details on kinetic parameters:
No data
Metabolites:
No data
Results with reference substance (positive control):
No data
Details on results:
See table below
Reported statistics:
No data

Any other information on results incl. tables

Bioconcentrationof MTBE in Cyprinus carpio

Test period (week)

1

2

3

4

Sample number

F-1A

F-1B

F-2A

F-2B

F-3A

F-3B

F-4A

F-4B

Fish body length

9.5

9.7

9.0

10.2

9.5

9.6

10.2

10.1

Fish body weight

20.2

21.2

17.3

23.8

22.0

22.6

24.3

24.0

Amount of MTBE in fish body (mg)

0.21

0.18

0.21

0.25

0.15

0.17

0.34

0.37

Concentration of MTBE in fish body (ppm)

10.4

8.5

12.1

10.5

7.3

7.5

14.0

15.4

Average concentration in water (ppm)

9.7

9.8

9.5

10.2

Bioconcentration factor

1.1

0.9

1.2

1.1

0.8

0.8

1.4

1.5

Applicant's summary and conclusion