Registration Dossier
Registration Dossier
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EC number: 200-293-7 | CAS number: 56-86-0
Endpoint summary
Administrative data
Description of key information
Acute oral study (comparable to OECD guidelines for acute oral toxicity): L-glutamic acid has been tested in a gavage study exposing 5 males and 5 females Wistar rat to 5110 mg/kg bw. After the observation period none of the animals died after dosing of 5110 mg/kg. No signs of toxicity was observed in the animals after dosing of 5110 mg/kg. The LD50 was established to be > 5110 mg/kg bw.
Dermal acute toxicity (OECD 402/EEC-Directive 92/69 B.3, according to GLP principles):
L-Glutamic acid has been tested in a 24-hours, semi-occlusive study exposing 5 males and 5 females Wistar rat to 2000 mg/kg bw. No mortality occurred. Chromodacryorrhoea and/or scales on the treated skin area were observed for several animals on Days 1 and 5, respectively. No abnormalities were found at macroscopic post mortem examination of the animals. The LD50 was established to be > 2000 mg/kg bw.
No data is available on acute inhalation toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 110 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Based on the studies performed, L-Glutamic acid is not considered toxic via oral or dermal route, in acute toxicity tests.
Justification for classification or non-classification
Based on the information in the discussion mentioned above, the substance is not classified for acute toxicity according to DSD and CLP.
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