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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Prehled Prumyslove Toxikologie; Organicke Latky
Author:
Marhold, J.
Year:
1986
Bibliographic source:
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J.,Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,740,1986
Reference Type:
review article or handbook
Title:
RTECS NUMBER : AD8225000
Author:
RTECS database
Year:
2012
Bibliographic source:
RTECS (Registry of Toxic Effects of Chemical Substances):"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986 Volume(issue)/page/year: -,740,1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Standard Draize test
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
4'-aminoacetanilide
EC Number:
204-576-6
EC Name:
4'-aminoacetanilide
Cas Number:
122-80-5
IUPAC Name:
N-(4-aminophenyl)acetamide

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
100 mg
Duration of treatment / exposure:
24 hrs

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24 hrs
Reversibility:
not specified
Remarks on result:
other: Moderately irritating

Applicant's summary and conclusion

Interpretation of results:
moderately irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
4 ′ -Aminoacetanilide when applied at a concentration of 100 mg for 24 hours to rabbits eye resulted in a moderate irritation effect.
Executive summary:

4 ′ -Aminoacetanilide when applied at a concentration of 100 mg for 24 hours to rabbits eye resulted in a moderate irritation effect.