Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-157-5 | CAS number: 103-90-2
Adsorption / desorption
Administrative data
Link to relevant study record(s)
Description of key information
The Adsorption Coefficient of test substance paracetamol (CAS No.103-90-2)was determined as per the HPLC method (OECD Guideline-121). The Log Koc value was found to be 1.319 ± 0.002 at 25°C.The result indicate that the chemical Paracetamol is likely to to show negligible sorption to soil and sediment and show rapid migration to groundwater.
Key value for chemical safety assessment
- Koc at 20 °C:
- 20.844
Additional information
The adsorption coefficient Koc in soil and in sewage sludge paracetamol(CAS No. 103-90-2)was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 121 for testing of Chemicals.The reference substances were chosen according to structural similarity with the test substance and calibration graph was prepared. The reference substances were, 2-nitrobenzamide, p-Toluamide,4-methylaniline, Aniline, N-methyl aniline, and2,5-Dichloroaniline,having Kocvalue ranging from 1.45 to 2.58.The Log Kocvalue was found tobe1.319 ± 0.002at 25°C.The result indicate that the chemical Paracetamol is likely to to show negligible sorption to soil and sediment and show rapid migration to groundwater.
[LogKoc: 1.319]
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
