Registration Dossier
Registration Dossier
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EC number: 204-984-4 | CAS number: 130-26-7
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- No information
- Author:
- Oyo Yakuri
- Year:
- 1 977
- Bibliographic source:
- Pharmacometrics.(Oyo Yakuri Kenkyukai, CPO Box 180,Sendai 980-91, Japan) V.1-1967-Volume(issue)/page/year: 14,211,1977
- Reference Type:
- review article or handbook
- Title:
- RTECS NUMBER : VC5075000
- Author:
- RTECS database
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances): OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 14,211,1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from Pharmacometrics
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Clioquinol
- EC Number:
- 204-984-4
- EC Name:
- Clioquinol
- Cas Number:
- 130-26-7
- Molecular formula:
- C9H5ClINO
- IUPAC Name:
- 5-chloro-7-iodoquinolin-8-ol
- Details on test material:
- - Name of test material (as cited in study report): clioquinol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Type of inhalation exposure (if applicable):
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 7-17 day(s) after conception
- Control animals:
- not specified
Results and discussion
Results: maternal animals
Effect levels (maternal animals)
- Dose descriptor:
- other: TDLo - Lowest published toxic dose
- Effect level:
- 528 other: mg/kg
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Details on embryotoxic / teratogenic effects:
Specific Developmental Abnormalities - musculoskeletal system
Effects on Newborn - growth statistics (e.g.%, reduced weight gain)
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The developmental toxicity TDLo ( Lowest published toxic dose ) of clioquinol in rat by the oral exposure was observed at a dose concentration of 1528 mg/kg .
- Executive summary:
The developmental toxicity TDLo ( Lowest published toxic dose ) of clioquinol in rat by the oral exposure was observed at a dose concentration of 1528 mg/kg . This indicates that clioquinol does not exhibit toxic effects to rat by the oral route below the above mentioned dose.
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