Registration Dossier

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a very short abstract available

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Report Date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
no further details given

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
no further details given

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
no further details given
Duration of exposure:
no further details given
Doses:
a single application of 5 g/kg
No. of animals per sex per dose:
10 rabbits were exposed
Control animals:
not specified
Details on study design:
A dermal LD50 study was conducted on a group of 10 rabbits, and a single application of 5 g/kg was administered. The animals were observed for mortality and/or clinical signs for 14 day.
Statistics:
no further details given

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
not specified
Mortality:
no mortality observed
Clinical signs:
no adverse clinical cisgns reported
Body weight:
no further details given
Gross pathology:
no further details given
Other findings:
no further details given

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
LD50 > 5000 mg/kg
l-menthol appears to be non toxic in tested conditions.