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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: The study is not GLP compliant, no guidelines were strictely followed and only short documentation is available (publication).

Data source

Reference
Reference Type:
publication
Title:
The antiseptic value and toxicity of menthol isomers
Author:
Franck Wokes
Year:
1932
Bibliographic source:
Journal of Pharmacy and Pharmacology 5 (1932), pp. 233–244

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
none provided

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Doses:
Concentration of testing material in vehicle was between 10% and 20%.
2 to 4 mg/g bw of the solution was orally given to the mice.
No. of animals per sex per dose:
10 mice per dose
sex was not specified
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: several days
The mice were deprived of food several hours before gavage to ensure optimal absorption of l-menthol.

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
3.4 other: g/kg bw
Based on:
dissolved

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
The LD50 for L-menthol was found to be 3 g/kg bw in the study conditions.
L-menthol is then considered non toxic.