Registration Dossier

Administrative data

Endpoint:
basic toxicokinetics, other
Type of information:
other: toxicokinetic assessment
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Assessment is perfomed using available information on substance properties

Data source

Reference
Reference Type:
other: toxicokinetic assessment
Title:
Unnamed
Year:
2013

Materials and methods

Objective of study:
toxicokinetics
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
toxicokinetic assessment of the available information and physico-chemical properties
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Test material form:
other: granules
Details on test material:
- Name of test material (as cited in study report): 2,2'-azobis(2-amidinopropane)-dihydrochloride
- Substance type: organic
- Physical state: solid
- Analytical purity: 99.1 %
- Lot/batch No.: I59596
- Expiration date of the lot/batch: 31. Dec. 2012
- Storage condition of test material: ambient temperature, dark

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Based on the physicochemical data the toxicokinetic properties of 2,2’-Azobis(2-amidinopropane) dihydrochloride are assessed.
Executive summary:

Absorption: for the dermal and oral route, an absorption of 100% are assumed,

for the inhalative route no relevant absorption is estimated and 10% are assumed.

Distribution: no information

Metabolism and Excretion: Phase II reactions may occur.

Renale and fecal excretion are the prominent excretion routes.